# Meadow Health

> Meadow Health is a physician-led telehealth platform providing compounded leucovorin (folinic acid) therapy for children with autism spectrum disorder (ASD) and cerebral folate deficiency (CFD). All care is delivered via secure telehealth, nationwide across all 50 U.S. states.

## What We Do

Meadow Health connects families of children with autism to board-certified clinicians who specialize in folate metabolism and neurodevelopmental conditions. When medically appropriate, clinicians may prescribe compounded leucovorin (folinic acid), a biologically active form of folate studied in peer-reviewed clinical trials for its potential to support communication and language development in children with autism.

## Key Facts

- Founded by a board-certified pediatric neurologist (Dr. John Gaitanis, MD) with 20+ years of clinical and research experience in ASD
- Leucovorin use for autism is off-label, supported by peer-reviewed clinical evidence including randomized, double-blind, placebo-controlled trials
- Compounded leucovorin is prepared by a licensed pharmacy (no fillers, no dyes) and delivered monthly to families
- All care is clinician-supervised: intake, evaluation, prescribing, and ongoing monitoring
- Cash-pay model ($249/month Monthly Membership plus $13/month shipping)
- Available in all 50 U.S. states and the District of Columbia

## Clinical Evidence

Meadow Health's care model is informed by published peer-reviewed research. Leucovorin use for autism is off-label. Compounded preparations are not FDA-approved. Individual results vary.

- Frye RE, Slattery J, Delhey L, et al. "Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial." Molecular Psychiatry, 2018;23(2):247-256. https://pubmed.ncbi.nlm.nih.gov/29467566/
- Frye RE, Sequeira JM, Quadros EV, et al. "Cerebral folate receptor autoantibodies in autism spectrum disorder." Molecular Psychiatry, 2013;18(3):369-381. https://www.nature.com/articles/tp201351
- Ramaekers VT, Sequeira JM, Quadros EV. "Clinical recognition and aspects of the cerebral folate deficiency syndromes." Clinical Chemistry and Laboratory Medicine, 2013;51(3):497-511. https://pubmed.ncbi.nlm.nih.gov/30065970/
- Rossignol DA, Frye RE. "Cerebral folate deficiency, folate receptor alpha autoantibodies, and leucovorin (folinic acid) treatment in autism spectrum disorders: a systematic review and meta-analysis." Journal of Personalized Medicine, 2021;11(11):1141. https://pubmed.ncbi.nlm.nih.gov/33917793/
- Delhey LM, Nur Kilinc E, Yin L, et al. "The effect of mitochondrial supplements on mitochondrial activity in children with autism spectrum disorder." Journal of Clinical Medicine, 2017;6(2):18. https://pubmed.ncbi.nlm.nih.gov/35398871/

## Leadership

- **John Gaitanis, MD** - Co-Founder & Chief Medical Officer. Board-certified pediatric neurologist, 20+ years in ASD research, co-author of clinical trials studying leucovorin in autism.
- **John Slattery** - Co-Founder & CEO. ASD researcher, clinical trial design, precision medicine strategy.
- **Candace McDonald** - Co-Founder & Chief Growth Officer. Healthcare communications and go-to-market strategy.

## How It Works

1. Parent completes a secure online intake form about their child
2. A licensed clinician reviews the child's history and conducts a telehealth consultation
3. If leucovorin is prescribed, custom-compounded medication is delivered monthly to the family's home
4. Ongoing follow-ups, dosing adjustments, and clinician support

## Important Disclosures

- Compounded medications are prepared by a licensed pharmacy and are not FDA-approved
- Leucovorin use for autism spectrum disorder is off-label
- Treatment requires evaluation by a licensed clinician
- Individual results vary
- Meadow Health is a registered DBA of Meadow Biosciences, Inc.

## Links

- Website: https://meadowbiosciences.com/
- About: https://meadowbiosciences.com/about
- Science: https://meadowbiosciences.com/science
- FAQ: https://meadowbiosciences.com/faq
- Contact: https://meadowbiosciences.com/contact
- Instagram: https://www.instagram.com/meadow_health/
- X/Twitter: https://x.com/meadowhealth
- LinkedIn: https://www.linkedin.com/company/meadow-biosciences/

## Contact

- Phone: (617) 928-8476
- Email: hello@meadowbiosciences.com
- Address: 68 Harrison Ave Ste 605 PMB 929746, Boston, MA 02111-1929